Tyrosine Protein Kinase JAK1-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Tyrosine Protein Kinase JAK1 (Janus Kinase 1 or JAK1 or EC 2.7.10.2) - JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. JAK1 plays a critical role in initiating responses to multiple major cytokine receptor families.... more

Vulvar Cancer-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Vulvar cancer is a rare type of cancer. It forms in a woman's external genitals, called the vulva. The cancer usually develops slowly over several years. First, precancerous cells grow on vulvar skin. This is called vulvar intraepithelial neoplasia (VIN) , or dysplasia.... more

Bullous Pemphigoid-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Bullous pemphigoid is a chronic, inflammatory, subepidermal, blistering disease. If untreated, it can persist for months or years, with periods of spontaneous remissions and exacerbations. The disease can be fatal, particularly in patients who are debilitated. Report... more

Smoking Addiction-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) In smoking addiction, people experience an uncontrollable dependence on cigarettes, which on stopping will cause severe mental, emotional or physical reactions. People addicted to smoking develop tolerance to nicotine. Nicotine acts on acetylcholine receptors causing... more

Metachromatic Leukodystrophy-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. Symptoms include vision problems leading to blindness, personality changes, and motor disturbances such as clumsiness, muscle weakness (hypotonia)... more

Endometrial Cancer-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Endometrial cancer is cancer that starts in the endometrium, the lining of the uterus (womb) . Endometrial cancer is the most common type of uterine cancer. Although the exact cause of endometrial cancer is unknown, increased levels of estrogen appear to play a role.... more

Phosphatidylinositol 45 Bisphosphate 3 Kinase Catalytic Subunit Beta Isoform-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Phosphatidylinositol 4,5 Bisphosphate 3 Kinase Catalytic Subunit Beta Isoform (Phosphatidylinositol 4,5 Bisphosphate 3 Kinase 110 kDa Catalytic Subunit Beta or PIK3CB or EC 2.7.1.153) - Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit beta isoform... more

Short Bowel Syndrome-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Short bowel syndrome is a complex disease that occurs due to the physical loss or the loss of function of a portion of the small and/or large intestine. Symptoms include bloating, cramping, fatigue, heartburn, vomiting, weakness and diarrhea. Complications of short... more

Mucopolysaccharidosis III-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Mucopolysaccharidosis type III (MPS III) , also known as Sanfilippo syndrome, is an inherited metabolic disease caused by an absence or malfunctioning of certain enzymes needed to breakdown molecules called glycosaminoglycans (GAG) . Symptoms include seizures, hyperactivity,... more

Neuroblastoma-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Neuroblastoma is the cancer of the nerve tissues and neural crest cells of adrenal glands, neck, chest or spinal cord, occurring predominantly in children. It usually begins in the adrenal glands further spreading to other parts of the body. The predisposing factors... more

Mucopolysaccharidosis II-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Mucopolysaccharidosis type II (MPS II) , also known as Hunter syndrome, is a condition that affects many different parts of the body and occurs almost exclusively in males. Signs and symptoms include claw-like hands, protruding tongue, changing facial features, including... more

Retinal Vein Occlusion-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Retinal vein occlusion is a blockage in one of the veins returning blood flow from the retina. The retina is where images are converted to nerve signals. The primary symptom of retinal vein occlusion is a sudden painless change in vision. Predisposing factors are atherosclerosis,... more

Encephalopathy-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Encephalopathy is a term for any diffuse disease of the brain that alters brain function or structure. Symptoms include seizures, difficulty speaking or swallowing, and trembling, involuntary twitching and muscle weakness. Causes include traumas or injuries, genetic,... more

Dental Pain-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) A pain in the tooth is called dental pain. This can be caused by tooth decay, damaged filling, tooth fracture, etc. Symptoms of a toothache may include: tooth pain that may be sharp, throbbing, or constant. In some people, pain results only when pressure is applied... more

Peptic Ulcers-Pipeline Review H1 2017

(EMAILWIRE.COM, June 17, 2017 ) Peptic ulcers are open sores that develop on the inside lining of esophagus, stomach and the upper portion of small intestine. Symptoms include nausea or vomiting, unexplained weight loss, appetite changes and abdominal pain. Risk factors include smoking and alcoholism.... more